The fundamentals of Huntington’s disease: A neurodegenerative disorder characterized by motor, cognitive, and neuropsychiatric symptoms

Huntington's disease (HD) is a genetic neurodegenerative disorder that affects around 40,000 people in the US.^1,2 Its myriad motor, cognitive, and behavioral symptoms^2–5 have a profound effect on the lives of patients and their caregivers.^6–8 In the absence of disease-modifying therapy, effective management remains a challenge, though its key motor s